Endocrine Abstracts

Background: Despite the strong preclinical rationale, there are only very few data considered the utility of metformin, as a potential pain therapeutic in humans. The aim of this study was to determine, the association between metformin therapy and pressure pain threshold (PPT) in lean polycystic ovary syndrome (PCOS) women. We hypothesized that metformin therapy in lean PCOS women increases pressure pain threshold.Materials and methods: Twenty-seven lea...

Aim: Evaluation of pressure pain threshold and β-endorphin plasma level in lean women with polycystic ovary syndrome (PCOS) and healthy controls. The associations between β- endorphins and pressure pain threshold were also investigated.Materials and methods: In 48 lean women with polycystic ovary syndrome and 38 lean women without this disorder plasma β-endorphins and pressure pain thresholds were measured.Results: T...

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory and infertility. According to the widespread data it affects 3–10% of women in the procreative age. Although many research have been done, it is still unclear which of mechanisms are responsible for the development of PCOS. The most up-to-date scientific trial indicates that the evolution of PCOS is related to the activity of the endogenous opioid system but precise mechanism is...

Introduction: Incretins are peptide hormones, responsible for 70% of the insulin release after oral glucose intake. An impaired incretins secretion was noted in several conditions involving insulin resistance, including polycystic ovary syndrome (PCOS), known as the state with increased testosterone level. This paper considers a possible relationship between the level of free androgen index (FAI) and glucose-dependent insulinotropic peptide (GIP) among lean women affected by P...